КВИНАЗОЛИНЫ: ХИМИЯ, СИНТЕЗ И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ

Quinazoline derivatives constitute a prominent class of heterocyclic compounds with considerable importance in modern organic and medicinal chemistry. Due to their structural diversity and synthetic accessibility, these compounds exhibit a broad range of biological activities, including anticancer, antimicrobial, antiviral, anti-inflammatory, antitubercular, and tyrosine kinase inhibitory effects. This book presents a comprehensive overview of quinazoline chemistry, focusing on structural features, electronic properties, and both classical and contemporary synthetic methodologies. Special emphasis is placed on modern approaches such as multicomponent reactions, metal-catalyzed processes, and green chemistry strategies. Furthermore, the biological activities of quinazoline derivatives are discussed in detail, with attention to their mechanisms of action, molecular targets, and structure–activity relationships supported by representative examples from recent literature. Designed as an advanced academic reference, this work aims to support graduate students, researchers, and academics by integrating fundamental principles with current developments in quinazoline-based drug discovery.