Таблетки Панангин, покрытые пленочной крышкой, флакон 50 шт.

Pharmacological properties

Pharmacodynamics. potassium and magnesium ions as important intracellular cations are included in the work of a number of enzymes, in the process of linking macromolecules with subcellular elements and in the mechanism of muscle contraction at the molecular level. the ratio of extracellular and intracellular concentrations of potassium, calcium, sodium and magnesium ions affects the contractility of the myocardium. aspartate as an endogenous substance is a carrier of potassium and magnesium ions; has a pronounced affinity for cells, its salts undergo dissociation only to a small extent. as a result, ions penetrate into the intracellular space in the form of complex compounds. magnesium aspartate and potassium aspartate improve myocardial metabolism. insufficient content of potassium and magnesium in the body increases the risk of developing hypertension, atherosclerotic damage to coronary vessels, heart rhythm disorders, and myocardial pathology.

Pharmacokinetics. Magnesium. The total supply of magnesium in a human body with a body weight of 70 kg is on average 24 g (1000 mmol); more than 60% of magnesium is transferred to bone tissue and about 40% to skeletal muscles and other tissues. About 1% of the total supply of magnesium in the body is in the extracellular fluid, mainly in the blood plasma. In healthy adults, the magnesium content in blood plasma is in the range of 0.7-1.10 mmol/l.

The recommended dietary intake of magnesium for men is 350 mg/day, for women - 280 mg/day. The need for magnesium increases during pregnancy and breastfeeding.

Magnesium is absorbed in the gastrointestinal tract by active transport. The kidneys are the main regulator of magnesium balance in the body. 3-5% of ionized magnesium is excreted by the kidneys.

An increase in the volume of urine (for example, during therapy with highly effective loop diuretics) leads to an increase in the excretion of ionized magnesium. If the absorption of magnesium in the small intestine decreases, further hypomagnesemia leads to a decrease in its excretion (0.5 mmol/day).

Potassium. The total supply of potassium in the body of a person with a body weight of 70 kg is on average 140 g (3570 mmol). The total supply of potassium is slightly less in women than in men and slightly decreases with age. 2% of the total supply of potassium in the body is outside the cells, and the other 98% is inside the cells.

The optimal rate of potassium consumption with food is 3-4 g (75-100 mmol) per day. The main route of potassium excretion is renal (about 90% of potassium is excreted by the kidneys per day). The remaining 10% is excreted through the gastrointestinal tract. Thus, the kidneys are responsible for long-term homeostasis of potassium, as well as for the content of potassium in the blood plasma. In the short term, blood potassium is also regulated by the exchange of potassium between the intracellular and extracellular spaces.

Indication

Additional therapy for chronic heart diseases (with heart failure, in the post-infarction period), heart rhythm disorders (primarily with ventricular arrhythmias) on the recommendation of a doctor.

Additional therapy in the treatment of digitalis drugs on the recommendation of a doctor.

As a supplement to the diet to increase the amount of magnesium and potassium in the body.

Application

The usual daily dose for adults is 1-2 tablets 3 times a day. the dose can be increased to 3 tablets 3 times a day. gastric juice can reduce the effectiveness of the drug, so Panangin is recommended to be taken after a meal. the course of treatment is determined by the doctor.

Contraindication

Hypersensitivity to the active substances or any of the excipients of the drug.

ANN and CNN, Addison's disease, AV block III degree, cardiogenic shock (BP 90 mm Hg).

Side effects

From the side of the gastrointestinal tract: when using high doses of the drug, frequent stools may be noted.

According to some data, nausea, vomiting and abdominal pain may occur.

Special instructions

Panangin, as a drug containing potassium and magnesium, should be used with caution in patients with myasthenia gravis; in conditions that can lead to hyperkalemia, such as reduced kidney function, acute dehydration, most common tissue damage, in particular, severe burns. in this category of patients, it is recommended to regularly examine the concentration of electrolytes in the blood plasma.

Panangin film-coated tablets should not be prescribed to patients with gastroduodenal ulcers or obstruction.

Use during pregnancy and breastfeeding. To date, no adverse effects have been reported in this category of patients.

Children. It is not recommended to prescribe the drug to children due to insufficient experience with its use.

The ability to influence the speed of reaction when driving a motor vehicle or working with other mechanisms. The drug does not affect the ability to drive vehicles and other mechanisms.